Synchronous presentation of cutaneous CD30-positive large T-cell lymphoma and glomangioma of the upper lip: a case report

We report a rare case of synchronous presentation of cutaneous CD30 (cluster of differentiation 30)-positive anaplastic large T-cell lymphoma and glomangioma involving the labial mucosa of the upper lip, highlighting its diagnostic challenges and clinical significance. A 61-yearold woman presented with a mildly tender mucosal lump measuring approximately 7× 4× 2 mm on the inner aspect of the upper lip, without ulceration, discoloration, or other distinctive clinical features. An excisional biopsy was performed under local anesthesia. Histopathological examination revealed a high-grade lymphoproliferative lesion composed of pleomorphic large, atypical cells, consistent with anaplastic large cell lymphoma. Notably, the lymphomatous lesion was located over a well-circumscribed glomangioma characterized by dilated vascular channels. This case underscores the importance of maintaining a high index of suspicion and performing thorough histopathological and immunohistochemical evaluation of all excised lesions, even when clinical features suggest a benign process. The rarity of this synchronous presentation underscores the need for heightened diagnostic vigilance and contributes valuable insight to the existing literature on unusual tumor associations in the oral and maxillofacial region.