Structure and Dynamics of a Long-Acting Insulin Analog in Hexameric and Dihexameric States
. Overall, this study provides a structural-dynamic framework for gaining new insights into the dynamics of long-acting analog INSD and helps identify actionable sites for modulating insulin (analogs) dynamics toward designing more effective therapeutics.
Authors
- Hoang‐Vu Nguyen (ORCID: https://orcid.org/0000-0002-4825-948X)
- Türkan Haliloǧlu (ORCID: https://orcid.org/0000-0002-1279-5803)
- Hasan DeMi̇rci̇ (ORCID: https://orcid.org/0000-0002-9135-5397)
- İvet Bahar (ORCID: https://orcid.org/0000-0001-9959-4176)
- Esra Ayan (ORCID: https://orcid.org/0000-0001-7906-4426)
Institutions
- Koç University (TR)
- Stony Brook School (US)
- Boğaziçi University (TR)
- Stony Brook University (US)
Publication Details
- Journal
- bioRxiv (Cold Spring Harbor Laboratory)
- Published
- 2026-04-25
- DOI
- https://doi.org/10.64898/2026.04.23.720485
- Primary Topic
- Protein Structure and Dynamics
- Type
- article
- Field-Weighted Citation Impact
- 0.00