<i>Enterococcus faecalis</i> autolysin, EpaU, binds the enterococcal polysaccharide antigen via its teichoic acid-like repeats and modulates c-di-AMP signaling
possesses a mechanism that senses the integrity of the peptidoglycan meshwork and employs c-di-AMP to regulate cell turgor, potentially altering the antibiotic resistance. Importance: cell wall and may provide insight into the development of antimicrobial agents based on autolysins.
Authors
- Cameron W. Kenner
- Jeffrey S. Rush (ORCID: https://orcid.org/0000-0002-3674-8008)
- Konstantin V. Korotkov (ORCID: https://orcid.org/0000-0002-2182-6843)
- Svetlana Zamakhaeva (ORCID: https://orcid.org/0000-0001-9971-4211)
- Alexander E. Yarawsky (ORCID: https://orcid.org/0000-0002-5973-5058)
- Natalia Korotkova (ORCID: https://orcid.org/0000-0002-8696-4892)
- Parastoo Azadi (ORCID: https://orcid.org/0000-0002-6166-9432)
- Catherine T. Chaton (ORCID: https://orcid.org/0000-0002-2843-3559)
- Andrew B. Herr (ORCID: https://orcid.org/0000-0002-3598-3399)
- Nicholas R. Murner (ORCID: https://orcid.org/0009-0002-7263-7193)
- Lei Huang
Institutions
- Cincinnati Children's Hospital Medical Center (US)
- University of Kentucky (US)
- University of Georgia (US)
- Bioanalytica (Switzerland) (CH)
Publication Details
- Journal
- bioRxiv (Cold Spring Harbor Laboratory)
- Published
- 2026-04-25
- DOI
- https://doi.org/10.64898/2026.04.24.720668
- Primary Topic
- Antimicrobial Resistance in Staphylococcus
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Institute of General Medical Sciences