Identification of hsa-miR-144-3p as a novel immunotherapeutic target for glioblastoma based on disulfidptosis-related analysis

There is no relevant research on the effect of disulfidptosis-related microRNA (miRNA) on the immune microenvironment in glioblastoma (GBM). We integrated transcriptomic data from The Cancer Genome Atlas (TCGA), Gene Expression Omnibus (GEO) and Chinese Glioma Genome Atlas(CGGA) databases to comprehensively identify disulfidptosis-related miRNAs in GBM and evaluated their functional pathways and immunological relevance using bioinformatics approaches. We identified hsa-miR-144-3p as a key disulfidptosis-related miRNA significantly associated with GBM. Functional analyses revealed that miR-144-3p was markedly enriched in immune-related pathways and strongly correlated with stromal score, immune score, and tumor purity. Moreover, its expression was significantly associated with immune checkpoint expression and immune cell infiltration patterns, suggesting a pivotal role in modulating the tumor immune microenvironment. This study reveals that the disulfide-related gene miR-144-3p, as a potential key miRNA may improve the prognosis by regulating immune cell infiltration and promoting the expression of immune checkpoints in GBM and serve as a target in GBM treatment. Our findings also provide new insights into the mechanism of disulfidptosis in GBM.