A Novel Triose Phosphate Isomerase Inhibitor With Dual Trypanosomicidal Activity was Identified Using Artificial Intelligence‐Based Virtual Screening
= 12 ± 1 μM). These compounds exhibit favorable selectivity and toxicological profiles, as well as in vivo activity, indicating their potential for future drug development.
Authors
- Gloria Yaluff (ORCID: https://orcid.org/0000-0002-7568-4756)
- Elena Aguilera (ORCID: https://orcid.org/0000-0002-1052-687X)
- Aram Davtyan (ORCID: https://orcid.org/0000-0001-6328-8361)
- Guzmán Álvarez (ORCID: https://orcid.org/0000-0001-8385-6100)
- Nallely Cabrera (ORCID: https://orcid.org/0000-0001-8766-6996)
- Elva Serna
- Rachel Ramos
- Ruy Perez‐Montfort
Institutions
- Universidad de la República de Uruguay (UY)
- Atlas Scientific (United States) (US)
- Instituto de Investigaciones en Ciencias de la Salud (AR)
- Centro Uruguayo de Imagenología Molecular (UY)
- Universidad Nacional de Asunción (PY)
- Universidad Nacional Autónoma de México (MX)
Publication Details
- Journal
- ChemMedChem
- Published
- 2026-04-25
- DOI
- https://doi.org/10.1002/cmdc.202500896
- Primary Topic
- Protein Structure and Dynamics
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Comisión Sectorial de Investigación Científica