Thyroid Monitoring After Intravascular Iodinated Contrast Media in Infants and Children Through 3 Years of Age
In March 2022, the US Food and Drug Administration issued a drug safety communication (DSC) recommending monitoring of thyroid function in children up to 3 years of age who receive intravascular injection of iodinated contrast media (IV ICM) for medical imaging. In response, a group of pediatric and imaging experts convened to review the current scientific evidence on thyroid dysfunction after IV ICM and to provide recommendations on thyroid testing and management after IV ICM administration in infants and children. There are considerable gaps in knowledge related to the risk of thyroid dysfunction in young children exposed to IV ICM, and we strongly recommend that high-quality prospective studies be proposed and funded to clarify the incidence, risk modifiers, natural history, and outcomes of thyroid dysfunction after IV ICM exposure in this population.
Authors
- Ari J. Wassner (ORCID: https://orcid.org/0000-0003-0894-9301)
- Matthew A. Crystal (ORCID: https://orcid.org/0000-0002-1885-769X)
- Arash Salavitabar (ORCID: https://orcid.org/0000-0002-9632-4725)
- Audrey C. Marshall (ORCID: https://orcid.org/0000-0002-1971-5861)
- Amit Lahoti (ORCID: https://orcid.org/0000-0003-0039-8701)
- Liuska Pesce (ORCID: https://orcid.org/0000-0002-8753-8166)
- Lucy D. Mastrandrea (ORCID: https://orcid.org/0000-0002-6031-0153)
- Jonathan D. Wasserman (ORCID: https://orcid.org/0000-0001-7088-8146)
- Andrew J. Bauer (ORCID: https://orcid.org/0000-0002-3952-881X)
- Brent M. Gordon (ORCID: https://orcid.org/0000-0002-7671-3766)
- Robert Rapaport (ORCID: https://orcid.org/0000-0002-0915-3551)
- Bridget Hughes
- Jonathan R. Dillman
- Monica Forbes-Amrein
- Kathleen Bethin
- Ryan S. Miller
- Catherine A. Dinauer
Institutions
- University of Iowa (US)
- Cincinnati Children's Hospital Medical Center (US)
- Boston Medical Center (US)
- Nationwide Children's Hospital (US)
- New Haven Public Schools (US)
- Sinai Hospital (US)
- Hospital for Sick Children (CA)
- Rady Children's Hospital-San Diego (US)
- Presbyterian Hospital (US)
- Indiana University School of Medicine
- Indiana University – Purdue University Indianapolis (US)
- University at Buffalo, State University of New York (US)
- University of Pennsylvania (US)
- Icahn School of Medicine at Mount Sinai (US)
Publication Details
- Journal
- PEDIATRICS
- Published
- 2026-04-27
- DOI
- https://doi.org/10.1542/peds.2026-076640
- Primary Topic
- Acute Kidney Injury Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00