Review of Organophosphorus Herbicide: Distribution of Residues, Toxicity Effects, Mechanisms, and Developing Trends Studies

Organophosphorus herbicides play an important role in agricultural development and are widely used worldwide. Glyphosate, glufosinate, DMPA, amiprophos-methyl, butamifos, piperophos, and other organophosphorus herbicides are overused worldwide. Organophosphorus herbicides are detected in different environmental media and play a toxic role in causing ecological health risks, causing serious concern among people. This review discusses the concentration levels of organophosphorus herbicides in water, soil, plants, and other environmental media and finds that the content of organophosphorus herbicides in soil is high, the concentration range is 12-129 μg/g, and finally summarizes the concentration levels of organophosphorus herbicides in organisms and human beings and finds that the concentration of organophosphorus herbicides in pesticide industry workers is relatively high. From the point of view of detection methods, the traditional methods and advanced technologies of herbicide detection are discussed in detail, and the advantages and disadvantages of these methods are pointed out. Finally, the ecological health risks, toxic effects, and molecular mechanisms of organophosphorus herbicides are discussed. Epidemiological investigations in China, Africa, and America showed that organophosphorus herbicides were prone to induce neurotoxicity, genotoxicity, and metabolic toxicity. These findings provide a theoretical basis for environmental management and ecological health risk assessment of organophosphorus herbicides.

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Publication Details

Journal
Journal of Applied Toxicology
Published
2026-04-26
DOI
https://doi.org/10.1002/jat.70222
Primary Topic
Pesticide and Herbicide Environmental Studies
Type
article
Field-Weighted Citation Impact
0.00

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article

Review of Organophosphorus Herbicide: Distribution of Residues, Toxicity Effects, Mechanisms, and Developing Trends Studies

Yangyang Ding, Emmanuel Sunday Okeke, Guanghua Mao, Chaoqiong Wu et al.
Journal of Applied Toxicology
Pesticide and Herbicide Environmental Studies
article

Review of Organophosphorus Herbicide: Distribution of Residues, Toxicity Effects, Mechanisms, and Developing Trends Studies

Yangyang Ding, Emmanuel Sunday Okeke, Guanghua Mao, Chaoqiong Wu, Xin Geng, Xiangyang Wu, Yao Chen, Xiangting Wang, Weiwei Feng
article en

Abstract

Organophosphorus herbicides play an important role in agricultural development and are widely used worldwide. Glyphosate, glufosinate, DMPA, amiprophos-methyl, butamifos, piperophos, and other organophosphorus herbicides are overused worldwide. Organophosphorus herbicides are detected in different environmental media and play a toxic role in causing ecological health risks, causing serious concern among people. This review discusses the concentration levels of organophosphorus herbicides in water, soil, plants, and other environmental media and finds that the content of organophosphorus herbicides in soil is high, the concentration range is 12-129 μg/g, and finally summarizes the concentration levels of organophosphorus herbicides in organisms and human beings and finds that the concentration of organophosphorus herbicides in pesticide industry workers is relatively high. From the point of view of detection methods, the traditional methods and advanced technologies of herbicide detection are discussed in detail, and the advantages and disadvantages of these methods are pointed out. Finally, the ecological health risks, toxic effects, and molecular mechanisms of organophosphorus herbicides are discussed. Epidemiological investigations in China, Africa, and America showed that organophosphorus herbicides were prone to induce neurotoxicity, genotoxicity, and metabolic toxicity. These findings provide a theoretical basis for environmental management and ecological health risk assessment of organophosphorus herbicides.

Journal of Applied Toxicology
Jiangsu University (CN), Jiangsu University of Science and Technology (CN), Jiangsu University of Technology (CN), Changzhou University (CN)
National Natural Science Foundation of China
Openalex Percentile: Top 9%
Pesticide and Herbicide Environmental Studies
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