Alteration of fimbria-mediated biofilm formation and virulence in the zoonotic pathogen <i>Edwardsiella piscicida</i> by sub-inhibitory concentrations of erythromycin exposures

. Our study reveals a new aspect of antibiotic functioning as a signaling molecule that modulates biofilm-related-gene expression and virulence in fish pathogen. This study demonstrates the comprehensive molecular response of the fish pathogen to environmentally discharged erythromycin. Additionally, the study provides scientific evidence for the hypertoxicity of pathogens through the indiscriminate use of antibiotics-ultimately leading to detrimental effects to the fishery industry. IMPORTANCE: evidence that sub-therapeutic antibiotics reshape bacterial behavior and host-pathogen interactions. This study highlights an underappreciated ecological and economic risk of indiscriminate antibiotic use in aquaculture, with direct implications for fish health, disease management, and environmental safety.

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Publication Details

Journal
Microbiology Spectrum
Published
2026-04-27
DOI
https://doi.org/10.1128/spectrum.00366-26
Primary Topic
Aquaculture disease management and microbiota
Type
article
Field-Weighted Citation Impact
0.00

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article

Alteration of fimbria-mediated biofilm formation and virulence in the zoonotic pathogen Edwardsiella piscicida by sub-inhibitory concentrations of erythromycin exposures

Yogini Jaiswal, Aaron Yerke, Ho Young Kang, Leonard Williams et al.
Microbiology Spectrum
Aquaculture disease management and microbiota
article

Alteration of fimbria-mediated biofilm formation and virulence in the zoonotic pathogen Edwardsiella piscicida by sub-inhibitory concentrations of erythromycin exposures

Yogini Jaiswal, Aaron Yerke, Ho Young Kang, Leonard Williams, Jin‐Young Yang, Sungmin Hwang, Ki Hwan Moon, J H Park, Se-Won Baek, Hyejung Jung, Ho Sung Kim
article en

Abstract

. Our study reveals a new aspect of antibiotic functioning as a signaling molecule that modulates biofilm-related-gene expression and virulence in fish pathogen. This study demonstrates the comprehensive molecular response of the fish pathogen to environmentally discharged erythromycin. Additionally, the study provides scientific evidence for the hypertoxicity of pathogens through the indiscriminate use of antibiotics-ultimately leading to detrimental effects to the fishery industry. IMPORTANCE: evidence that sub-therapeutic antibiotics reshape bacterial behavior and host-pathogen interactions. This study highlights an underappreciated ecological and economic risk of indiscriminate antibiotic use in aquaculture, with direct implications for fish health, disease management, and environmental safety.

Microbiology Spectrum
University of North Carolina at Charlotte (US), Korea Maritime and Ocean University (KR), North Carolina Agricultural and Technical State University (US), National Fisheries Institute (US), Pusan National University (KR)
National Research Foundation of Korea
Openalex Percentile: Top 8%
Aquaculture disease management and microbiota
DOIOpen Access PDFOpenAlex
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