Discovery of Small Molecule Inhibitors of PCSK9 Using Virtual Screening as Potential Therapeutics for Atherosclerosis

<p style="margin-left:0cm; margin-right:0cm">High LDL cholesterol can cause heart disease. Current treatments like statins are not always effective, so new therapies are needed. PCSK9 is a protein that reduces the number of LDL receptors in the liver, which keeps cholesterol in the blood, making it a strong target for

Authors

Publication Details

Journal
European Journal of Biomedical and Life Sciences
Published
2026-03-31
DOI
https://doi.org/10.29013/ejbls-26-1-15-32
Primary Topic
Lipoproteins and Cardiovascular Health
Type
article
Field-Weighted Citation Impact
0.00
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article

Discovery of Small Molecule Inhibitors of PCSK9 Using Virtual Screening as Potential Therapeutics for Atherosclerosis

Matthew N. Siciliano
European Journal of Biomedical and Life Sciences
Lipoproteins and Cardiovascular Health
article

Discovery of Small Molecule Inhibitors of PCSK9 Using Virtual Screening as Potential Therapeutics for Atherosclerosis

Matthew N. Siciliano
article en

Abstract

<p style="margin-left:0cm; margin-right:0cm">High LDL cholesterol can cause heart disease. Current treatments like statins are not always effective, so new therapies are needed. PCSK9 is a protein that reduces the number of LDL receptors in the liver, which keeps cholesterol in the blood, making it a strong target for

European Journal of Biomedical and Life Sciences
Good health and well-being
Openalex Percentile: Top 6%
Lipoproteins and Cardiovascular Health
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