Spray-freeze-drying aprepitant with hydroxypropyl cellulose increases nasal bioavailability
values, HPC-based SFD formulations enhanced aprepitant bioavailability by at least threefold. These findings underline the potential of SFD as a formulation platform for the nasal delivery of poorly water-soluble drugs.
Authors
- Klaus Wunderling (ORCID: https://orcid.org/0000-0003-1237-7510)
- Yann Pellequer
- Annika Rautenberg
- Jan Kožák
- Claire Chrétien
- Paul Bühlbecker
- Alf Lamprecht
- Alexander Pfeifer
- Edmont Stoyanov
Institutions
- University of Bonn (DE)
- Inserm (FR)
- University Hospital Bonn (DE)
- Mitsubishi Chemical (Germany) (DE)
- Université Marie et Louis Pasteur (FR)
- Université de Franche-Comté (FR)
Publication Details
- Journal
- International Journal of Pharmaceutics X
- Published
- 2026-04-26
- DOI
- https://doi.org/10.1016/j.ijpx.2026.100551
- Primary Topic
- Advanced Drug Delivery Systems
- Type
- article
- Field-Weighted Citation Impact
- 0.00