The predictive value of serum CXCL2 and CXCL8 levels for early neurological deterioration in patients with penetrating artery disease-type ischaemic stroke

OBJECTIVE: To evaluate whether serum C-X-C motif chemokine ligand 2 (CXCL2) and C-X-C motif chemokine ligand 8 (CXCL8) predict early neurological deterioration (END) in penetrating artery disease (PAD)-type ischaemic stroke. METHODS: = 124) groups. Bioinformatics analysis using the GEO database and protein-protein interaction (PPI) analysis were performed. Serum CXCL2 and CXCL8 levels were measured by enzyme-linked immunosorbent assay (ELISA). Pearson correlation, receiver operating characteristic (ROC) curve, and logistic regression analyses were performed, followed by nomogram construction. RESULTS: > 0.05). CONCLUSIONS: Serum CXCL2 and CXCL8 demonstrate potential as biomarkers for identifying END in acute PAD.