Preclinical efficacy of dendritic cells loaded with newly identified HPV11 E6-derived CD8+ T cell epitopes
T cells in the tumors. In addition, BMDCs loaded with both peptide epitopes, p11 and p22, were more effective than BMDCs loaded with single epitopes in the suppression of TC-1.HPV11 E6/7 tumor progression. Data from this study will help with the rational design of therapeutic strategies for the diseases associated with HPV11 infection.
Authors
- Chao Gu (ORCID: https://orcid.org/0000-0002-0486-8611)
- Laurie Baert (ORCID: https://orcid.org/0000-0001-8309-7132)
- Agnes Yang
- David G. Lott
- Kieth Knutson
- HyeMee Joo
- SangKon Oh
- Richard Kennedy
Institutions
- Mayo Clinic (US)
- WinnMed (US)
- Mayo Clinic in Arizona (US)
- Mayo Clinic Hospital (US)
- Mayo Clinic in Florida (US)
Publication Details
- Journal
- npj Vaccines
- Published
- 2026-04-27
- DOI
- https://doi.org/10.1038/s41541-026-01466-0
- Primary Topic
- Immunotherapy and Immune Responses
- Type
- article
- Field-Weighted Citation Impact
- 0.00