Avaliação do metabolismo oxidativo cerebral e hepático utilizando risperidona em um modelo subagudo em ratos (Rattus norvegicus)

Objectives: this study aimed to evaluate the impact of subacute risperidone administration on antioxidant enzyme activity and lipid peroxidation in rats. Methods: a total of fifteen male Holtzman albino rats were randomly assigned to a Control group (n = 5, no risperidone) and two treatment groups (n = 5 per group) receiving 0.4 mg·kg-1·day-1 and 4.0 mg·kg-1·day-1 risperidone, administered via orogastric gavage for 20 consecutive days. After treatment, brain and liver tissues were collected. The activity of superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), glucose-6-phosphate dehydrogenase (G6PDH), and glutathione S-transferase (GST) was analyzed. Reduced glutathione (GSH) levels and lipid peroxidation, measured as thiobarbituric acid reactive substances (TBARS), were quantified. Results: findings indicate that in brain tissue, both doses significantly increased CAT activity and decreased the SOD/CAT ratio, and that the high dose significantly reduced TBARS levels. In liver tissue, a significant increase in CAT activity was observed with the high dose. Furthermore, both doses significantly increased G6PDH activity and reduced TBARS levels. Conclusions: these results underscore the influence of risperidone on cerebral and hepatic oxidative metabolism during the subacute phase.