Chronic tubal ectopic pregnancy with undetectable serum β-hCG mimicking a large ovarian endometrioma: A case report

Ectopic pregnancy is usually associated with detectable serum β-human chorionic gonadotropin levels. A rare case of chronic tubal ectopic pregnancy with undetectable beta human chorionic gonadotrophin (β-HCG) that mimicked a large ovarian endometrioma is reported. A 34-year-old multiparous woman presented with prolonged abnormal uterine bleeding and chronic pelvic pain following a 45-day delay in menstruation. Imaging revealed a large complex left adnexal mass measuring 12 × 10 × 7 cm, highly suggestive of ovarian endometrioma. Surgical exploration demonstrated a densely adherent adnexal mass requiring left salpingo-oophorectomy. Histopathological examination confirmed chronic tubal ectopic pregnancy. This case highlights that ectopic pregnancy should remain in the differential diagnosis of adnexal masses even when serum β-hCG is undetectable.

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Publication Details

Journal
Case Reports in Women s Health
Published
2026-04-25
DOI
https://doi.org/10.1016/j.crwh.2026.e00814
Primary Topic
Ectopic Pregnancy Diagnosis and Management
Type
article
Field-Weighted Citation Impact
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article

Chronic tubal ectopic pregnancy with undetectable serum β-hCG mimicking a large ovarian endometrioma: A case report

Ahlam Al-Kholani, Laiqah Al-Dhaheri
Case Reports in Women s Health
Ectopic Pregnancy Diagnosis and Management
article

Chronic tubal ectopic pregnancy with undetectable serum β-hCG mimicking a large ovarian endometrioma: A case report

Ahlam Al-Kholani, Laiqah Al-Dhaheri
article en

Abstract

Ectopic pregnancy is usually associated with detectable serum β-human chorionic gonadotropin levels. A rare case of chronic tubal ectopic pregnancy with undetectable beta human chorionic gonadotrophin (β-HCG) that mimicked a large ovarian endometrioma is reported. A 34-year-old multiparous woman presented with prolonged abnormal uterine bleeding and chronic pelvic pain following a 45-day delay in menstruation. Imaging revealed a large complex left adnexal mass measuring 12 × 10 × 7 cm, highly suggestive of ovarian endometrioma. Surgical exploration demonstrated a densely adherent adnexal mass requiring left salpingo-oophorectomy. Histopathological examination confirmed chronic tubal ectopic pregnancy. This case highlights that ectopic pregnancy should remain in the differential diagnosis of adnexal masses even when serum β-hCG is undetectable.

Case Reports in Women s HealthVol. 50
Sana'a University (YE), Amran University (YE)
Openalex Percentile: Top 16%
Ectopic Pregnancy Diagnosis and Management
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Chronic tubal ectopic pregnancy with undetectable serum β-hCG mimicking a large ovarian endometrioma: A case report — Ahlam Al-Kholani, Laiqah Al-Dhaheri · Case Reports in Women s Health (2026) | TGRS Research Map | TGRS