Structure, Biosynthesis, and Bioactivity of Nostolysamides
studies of NpuN show relatively broad substrate specificity, with NpuN conjugating various acyl groups from acyl-CoA substrates to Lys1 in the nostolysamides. The acylation did not appreciably change the antifungal and antimicrobial activity of nostolysamide, showing that it is not required for these activities.
Authors
- Wilfred A. van der Donk (ORCID: https://orcid.org/0000-0002-5467-7071)
- Enleyona Weir
- Ivan Anterola (ORCID: https://orcid.org/0009-0002-5983-8943)
Institutions
- University of Illinois Urbana-Champaign (US)
Publication Details
- Journal
- Biochemistry
- Published
- 2026-04-24
- DOI
- https://doi.org/10.1021/acs.biochem.6c00103
- Primary Topic
- Microbial Natural Products and Biosynthesis
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Howard Hughes Medical Institute
- National Institute of Allergy and Infectious Diseases