Design, Synthesis, and Biological Evaluation of Indolin‐2‐One–Matrine Derivatives as Potential VEGFR‐2‐Targeting Agents for Hepatocellular Carcinoma
= 253.51 ± 1.21 nM), and docking/MD simulations suggested stable binding within the VEGFR-2 ATP-binding pocket. Collectively, J9 represents a promising matrine-derived antitumor candidate with potential VEGFR-2-targeting activity.
Authors
- Zexu Xing
- Yongquan Wei
- Ziyi Wang (ORCID: https://orcid.org/0000-0003-3219-9950)
- Lisheng Wang (ORCID: https://orcid.org/0000-0003-2655-0724)
- Lihe Jiang
Institutions
- Guangxi University (CN)
- Guangxi Medical University (CN)
- Affiliated Hospital of Youjiang Medical University for Nationalities (CN)
Publication Details
- Journal
- ChemMedChem
- Published
- 2026-04-25
- DOI
- https://doi.org/10.1002/cmdc.70283
- Primary Topic
- Bioactive natural compounds
- Type
- article
- Field-Weighted Citation Impact
- 0.00