Cross-ancestry evaluation of idiopathic pulmonary fibrosis genetic risk variants
promoter variant rs35705950 emerged as the dominant and most consistent signal across ancestries. Our findings highlight the need for larger, well-characterised studies in understudied populations to support robust discovery and translation.
Authors
- Ritah Nabunje (ORCID: https://orcid.org/0000-0001-9094-8687)
- C Flores
- Tamara Hernández-Beeftink
- Toby M. Maher (ORCID: https://orcid.org/0000-0001-7192-9149)
- Myriam Aburto (ORCID: https://orcid.org/0000-0001-8644-1015)
- Ebrima Joof (ORCID: https://orcid.org/0000-0002-3367-0102)
- Olivia C. Leavy (ORCID: https://orcid.org/0000-0002-1503-5535)
- Phil Molyneux
- RJ Allen
- Amaia Urrutia
- Louise V Wain
- Beatriz Guillen-Guio
- Imre Noth
- R Gisli Jenkins
Institutions
- University of Southern California (US)
- University of Leicester (GB)
- University of Michigan (US)
- Instituto de Salud Carlos III (ES)
- University Hospitals of Leicester NHS Trust (GB)
- Hospital Universitario Nuestra Señora de Candelaria (ES)
- Universidad Fernando Pessoa Canarias (ES)
- Centro de Investigación Biomédica en Red de Enfermedades Respiratorias (ES)
- Instituto Tecnológico y de Energías Renovables (ES)
- NIHR Imperial Biomedical Research Centre (GB)
- Hospital de Galdakao (ES)
- Hospital de Cruces (ES)
- NIHR Leicester Biomedical Research Centre (GB)
- Imperial College London (GB)
- University of Virginia (US)
Publication Details
- Journal
- medRxiv
- Published
- 2026-04-25
- DOI
- https://doi.org/10.64898/2026.04.17.26349970
- Primary Topic
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Type
- article
- Field-Weighted Citation Impact
- 0.00