XL-MS and De Novo Protein Design Identified a Common Motif for TREM2 Binding

-designed mini-protein binders, which show the same binding mode as identified by our XL-MS experiment. These results establish a robust framework for developing mini-protein-based TREM2 agonists.

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Publication Details

Journal
bioRxiv (Cold Spring Harbor Laboratory)
Published
2026-04-24
DOI
https://doi.org/10.64898/2026.04.23.720433
Primary Topic
Neuroinflammation and Neurodegeneration Mechanisms
Type
article
Field-Weighted Citation Impact
0.00

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XL-MS and De Novo Protein Design Identified a Common Motif for TREM2 Binding

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bioRxiv (Cold Spring Harbor Laboratory)
Neuroinflammation and Neurodegeneration Mechanisms
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XL-MS and De Novo Protein Design Identified a Common Motif for TREM2 Binding

Haifan Wu, Kalana Pitakatuwana, Emmanuel Ajiboye, Vincent Duong, Sophia Wier, Doniesha Perera
article en

Abstract

-designed mini-protein binders, which show the same binding mode as identified by our XL-MS experiment. These results establish a robust framework for developing mini-protein-based TREM2 agonists.

bioRxiv (Cold Spring Harbor Laboratory)
Wichita State University (US)
National Institute on Aging
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Openalex Percentile: Top 11%
Neuroinflammation and Neurodegeneration Mechanisms
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