International Collaborative Study on Human Papillomavirus Analytical Thresholds for Sensitivity and Specificity in Cervical Screening
human cells gave similar results. Comparator assay testing using manufacturer-defined thresholds achieved high ICC-weighted sensitivity (96.61%) but low specificity (82.50%). This international collaborative study has identified HPV analytical detection thresholds optimizing the sensitivity and specificity of cervical screening.
Authors
- K. Miriam Elfström (ORCID: https://orcid.org/0000-0002-0514-7226)
- Gerald L. Murray (ORCID: https://orcid.org/0000-0003-3330-4433)
- Joakim Dillner (ORCID: https://orcid.org/0000-0001-8588-6506)
- Laila Sara Arroyo Mühr (ORCID: https://orcid.org/0000-0003-2498-5206)
- Jean‐Luc Prétet (ORCID: https://orcid.org/0000-0002-8430-214X)
- Prisha Balgovind (ORCID: https://orcid.org/0009-0006-9900-6622)
- Nina Redzic (ORCID: https://orcid.org/0000-0003-4774-2055)
- Kate Cuschieri (ORCID: https://orcid.org/0000-0002-2604-3928)
- Murat Gültekin (ORCID: https://orcid.org/0000-0002-4221-4459)
- Emel Yilmaz (ORCID: https://orcid.org/0000-0002-2368-7402)
- Anja Oštrbenk
- Quentin Lepiller (ORCID: https://orcid.org/0000-0003-2892-4216)
- Marianna Martinelli (ORCID: https://orcid.org/0000-0003-2273-6986)
- Mario Poljak (ORCID: https://orcid.org/0000-0002-3216-7564)
- Davy Vanden Broeck (ORCID: https://orcid.org/0000-0001-9381-4158)
- Steffi Silling (ORCID: https://orcid.org/0000-0002-9555-3876)
- Linzi Connor (ORCID: https://orcid.org/0000-0002-6036-6261)
- C. Brown
- Yalin Kiliç
- Clementina Cocuzza
- Suzanne Marie Garland
- Allan Campbell
- Rita Pereira
Institutions
- Centre National de la Recherche Scientifique (FR)
- MEF University (TR)
- Royal Women's Hospital (AU)
- University of Ljubljana (SI)
- Edinburgh Royal Infirmary (GB)
- Karolinska Institutet (SE)
- Laboratoire Chrono-Environnement (FR)
- Laboratoire National de Référence (MA)
- Regional Cancer Center (US)
- Sonic Healthcare (Germany) (DE)
- Kent Hastanesi (TR)
- Fatih Sultan Mehmet Waqf University (TR)
- Murdoch Children's Research Institute (AU)
- University Hospital Cologne (DE)
- Melbourne Health (AU)
- Hacettepe University (TR)
- University of Milano-Bicocca (IT)
Publication Details
- Journal
- Journal of Medical Virology
- Published
- 2026-04-25
- DOI
- https://doi.org/10.1002/jmv.70936
- Primary Topic
- Cervical Cancer and HPV Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Bill and Melinda Gates Foundation
- European Commission
- Cancerfonden
- Bundesministerium für Gesundheit
- Vetenskapsrådet
- Türkiye Bilimsel ve Teknolojik Araştırma Kurumu
- Horizon 2020 Framework Programme
- Medical Research Council
- National Health and Medical Research Council