Anthraquinone‐Based Electron Reservoir‐Pump Photosensitizer Generating Radical Ion Pairs for Metabolism‐Targeted Photodynamic Therapy

), facilitating intersystem crossing. Notably, AQTPE nanoparticles exhibited potent type I photodynamic activity and robust tumor suppression even under hypoxic conditions. This study establishes a molecular electronegativity-modulation framework for integrating electron reservoir-pump systems within single-component photosensitizers, offering a general design principle for next-generation metabolism-targeted and hypoxia-tolerant photosensitizers.