XIAP Deficiency Impairs Colonic Tuft Cell Development and Predisposes to Crohn's Disease
mice. Consistently, in an XIAP‑-deficient CD patient, treatment with a selective JAK1 inhibitor effectively increased tuft cell proportion and alleviated colonic symptoms. In conclusion, our study identifies tuft cell deficiency as a trigger of intestinal pathology in XIAP‑-deficient Crohn's disease and suggests JAK inhibition as a promising therapeutic strategy.
Authors
- Wenhao Zhou (ORCID: https://orcid.org/0000-0001-8956-7238)
- L F Zhang
- Huifang Xian (ORCID: https://orcid.org/0000-0003-1467-2644)
- Zhanghua Chen (ORCID: https://orcid.org/0000-0002-2505-0675)
- Kanghua Zhong (ORCID: https://orcid.org/0000-0003-1386-7087)
- Rongli Fang
- Yuyin Qi
- Hanhan Chen
- M Q Zhang
- Qiuhua Wang (ORCID: https://orcid.org/0000-0002-0017-9026)
- Ming Zou (ORCID: https://orcid.org/0000-0003-0352-2851)
- Yuxia Zhang (ORCID: https://orcid.org/0000-0003-2715-0925)
- Changjun Nie
- Huibo Wu
- Jianheng Zhu
- L L Geng
- Xiang Peng
- Hirokazu Kanegane
- Lili Li
- Xi Yang
- Min Zhi
- Ning Tang
- Liren Tan
- Chaorui Tang
- Jiwei Huang
- Xiaodong Zhao
- James E. Vince
- Wei Wang
- Lei Huang
Institutions
- Tokyo Medical and Dental University (JP)
- Sun Yat-sen University (CN)
- Walter and Eliza Hall Institute of Medical Research (AU)
- Liuzhou Maternal and Child Health Hospital (CN)
- Sixth Affiliated Hospital of Sun Yat-sen University (CN)
- Guangzhou Women and Children Medical Center (CN)
- Children's Hospital of Chongqing Medical University (CN)
- Chongqing Medical University (CN)
- Guangzhou Medical University (CN)
Publication Details
- Journal
- MedComm
- Published
- 2026-04-25
- DOI
- https://doi.org/10.1002/mco2.70745
- Primary Topic
- Immunodeficiency and Autoimmune Disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China