Breaking the barrier: Synergistic 2B4.4-1BB signaling potentiates HER2-CAR NK cells to penetrate and destroy ADCC-resistant tumors
• Dual 2B4·4-1BB signaling reprograms HER2-CAR NK-92 cells for durable antitumor power • Synergistic costimulation drives deep infiltration of mAbs resistant tumor spheroids • Dual 2B4·4-1BB CAR NK-92 therapy achieves long-lasting tumor remission • This next-generation CAR-NK design overcomes immune and TME derived resistance
Authors
- István Rebenku (ORCID: https://orcid.org/0000-0002-4959-7587)
- Árpád Szöőr (ORCID: https://orcid.org/0000-0002-3727-6129)
- Bence Gergely (ORCID: https://orcid.org/0000-0001-9005-6910)
- György Vereb (ORCID: https://orcid.org/0000-0003-2157-3265)
- Márk Vereb
Institutions
- University of Debrecen (HU)
Publication Details
- Journal
- Cancer Letters
- Published
- 2026-04-25
- DOI
- https://doi.org/10.1016/j.canlet.2026.218534
- Primary Topic
- Immune Cell Function and Interaction
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Nemzeti Kutatási és Technológiai Hivatal