Syringomatous Adenoma of the Nipple: A Rare Benign Breast Tumor

Syringomatous adenoma of the nipple (SAN) is a rare benign tumor of the breast that can become a clinical and diagnostic challenge, as it can be misdiagnosed as invasive carcinoma due to its infiltrative nature. The treatment of choice is wide resection with clear margins. There are limited published cases of SAN. We present a case of SAN in a 42-year-old female patient, with regard to clinical manifestations, histopathologic and surgical findings, and differential diagnosis from other entities. A literature review of histologically confirmed cases of SAN revealed a total of 61 cases, including ours.

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Publication Details

Journal
Cureus
Published
2026-04-25
DOI
https://doi.org/10.7759/cureus.107686
Primary Topic
Breast Lesions and Carcinomas
Type
article
Field-Weighted Citation Impact
0.00
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article

Syringomatous Adenoma of the Nipple: A Rare Benign Breast Tumor

Aristofania Simatou, George Simatos, Christos Kalyvopoulos, Ilianna Kougia et al.
Cureus
Breast Lesions and Carcinomas
article

Syringomatous Adenoma of the Nipple: A Rare Benign Breast Tumor

Aristofania Simatou, George Simatos, Christos Kalyvopoulos, Ilianna Kougia, Eleni Papaioannou
article en

Abstract

Syringomatous adenoma of the nipple (SAN) is a rare benign tumor of the breast that can become a clinical and diagnostic challenge, as it can be misdiagnosed as invasive carcinoma due to its infiltrative nature. The treatment of choice is wide resection with clear margins. There are limited published cases of SAN. We present a case of SAN in a 42-year-old female patient, with regard to clinical manifestations, histopathologic and surgical findings, and differential diagnosis from other entities. A literature review of histologically confirmed cases of SAN revealed a total of 61 cases, including ours.

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Breast Lesions and Carcinomas
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