Higher magnetic field NMR renders resolution enhancement on ganglioside GD3 catalyzed heterogeneous Aβ42 aggregates
are observed, indicating the presence of an ordered core within the lipid-associated aggregates. These results demonstrate that ultrahigh-field SSNMR can be advantageous in the characterization of heterogeneous amyloid assemblies and provides a promising approach for atomic-level investigation of biologically relevant, lipid-modulated Aβ aggregates.
Authors
- Jhinuk Saha (ORCID: https://orcid.org/0000-0002-5371-9014)
- Thirupati Ravula
- Ayyalusamy Ramamoorthy
Institutions
- Florida State University (US)
- Florida A&M University - Florida State University College of Engineering (US)
- Resonance Research (United States) (US)
Publication Details
- Journal
- Solid State Nuclear Magnetic Resonance
- Published
- 2026-04-25
- DOI
- https://doi.org/10.1016/j.ssnmr.2026.102093
- Primary Topic
- Advanced NMR Techniques and Applications
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Foundation for the National Institutes of Health