Zero-shot design of a <i>de novo</i> metalloenzyme
, comparable to characterized natural phosphatases. dEVA offers a general and modular strategy for the programmable design of protein function without dependence on natural templates, predefined motif, or evolutionary information.
Authors
- Simon Dürr (ORCID: https://orcid.org/0000-0002-4304-8106)
- Po‐Ssu Huang (ORCID: https://orcid.org/0000-0002-7948-2895)
- Irimpan I. Mathews (ORCID: https://orcid.org/0000-0001-6254-3519)
- Fanny Sunden (ORCID: https://orcid.org/0000-0003-4110-7384)
- Gina El Nesr (ORCID: https://orcid.org/0000-0003-4857-9464)
- Qi Wen (ORCID: https://orcid.org/0009-0009-1386-0329)
- Ritimukta Sarangi (ORCID: https://orcid.org/0000-0002-2764-2279)
- Ursula Roethlisberger
- Kewei Zhao
Institutions
- SLAC National Accelerator Laboratory (US)
- Stanford Synchrotron Radiation Lightsource (US)
- HES-SO Valais-Wallis (CH)
- École Polytechnique Fédérale de Lausanne (CH)
- Stanford University (US)
Publication Details
- Journal
- bioRxiv (Cold Spring Harbor Laboratory)
- Published
- 2026-04-24
- DOI
- https://doi.org/10.64898/2026.04.23.720277
- Primary Topic
- Metalloenzymes and iron-sulfur proteins
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung