Asparaginase activity levels and toxicity in children and adolescents with acute lymphoblastic leukemia
= 0.058). No association between SAA peak and/or trough levels and acute pancreatitis nor hypersensitivity was observed. SAA do not appear to predict the risk of ASP-related toxicities. Our data do not support individualized dosing to prevent toxicities such as thrombosis or pancreatitis. Larger prospective studies are required to help identify children at high risk of ASP-related toxicities.
Authors
- Tiago Nava (ORCID: https://orcid.org/0000-0002-8150-5478)
- Émilie Martineau
- Narcisse Singbo (ORCID: https://orcid.org/0000-0002-5009-2420)
- Thai Hoa Tran (ORCID: https://orcid.org/0000-0002-8712-6233)
- Marie-Pier Desjardins (ORCID: https://orcid.org/0000-0001-9584-2320)
- Yves Théorêt (ORCID: https://orcid.org/0000-0002-2353-860X)
- James A. Whitlock (ORCID: https://orcid.org/0000-0002-7887-0634)
- Caroline Laverdière (ORCID: https://orcid.org/0000-0002-4917-7152)
- Alexis Manirakiza
- Chantal Éthier
- Marie‐Claude Pelland‐Marcotte (ORCID: https://orcid.org/0000-0003-2364-7205)
- Héloïse Perrault
- Elsa Trombino (ORCID: https://orcid.org/0009-0007-4561-7126)
- Jean-Marie Leclerc (ORCID: https://orcid.org/0000-0002-1131-2064)
Institutions
- University of Toronto (CA)
- Children's Hospital of Eastern Ontario (CA)
- Great Ormond Street Hospital (GB)
- Hospital for Sick Children (CA)
- Centre Hospitalier Universitaire Sainte-Justine (CA)
- Centre hospitalier de l'Université Laval (CA)
- SickKids Foundation (CA)
- Université Laval (CA)
- University College London (GB)
- Université de Montréal (CA)
Publication Details
- Journal
- Leukemia & lymphoma/Leukemia and lymphoma
- Published
- 2026-04-25
- DOI
- https://doi.org/10.1080/10428194.2026.2656726
- Primary Topic
- Acute Lymphoblastic Leukemia research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Servier Canada