Comparative evaluation of the effect of lyophilised platelet rich plasma and micro-osteoperforation on the rate of orthodontic tooth movement in class I bimaxillary protrusion patients :A split mouth randomized trial

<p>BACKGROUND: Orthodontic tooth movement is often time-consuming and can cause patient discomfort. Various techniques to accelerate tooth movement such as micro-osteoperforation and platelet-rich plasma (PRP) have been extensively researched. PRP is an autologous component rich in growth factors and mediators that promote cell proliferation and differentiation, essential for orthodontic tooth movement. Freeze-drying PRP enhances its shelf life and clinical applicability.</p><p> </p><p> </p><p>AIM: The present study aims to evaluate the efficacy of lyophilised platelet-rich plasma</p><p> </p><p>(LPRP) and micro-osteoperforation (MOP) in accelerating canine retraction in patients with</p><p> </p><p>class I bimaxillary protrusion undergoing fixed orthodontic treatment.</p><p> </p><p> </p><p>MATERIALS AND METHOD: This randomized split-mouth clinical trial was conducted at the Department of Orthodontics and Dentofacial Orthopaedics, Rajas Dental College and</p><p> </p><p>Hospitals, Tirunelveli. Nine patients with Class I bimaxillary protrusion were randomly assigned to receive either MOP or LPRP on the contralateral side. Tooth movement was assessed at one- and two-months post-intervention using dental cast. Statistical analysis of the data was performed, with a p-value of < 0.05 considered statistically significant.</p><p> </p><p> </p><p>RESULTS: The mean age of the participants was 21.00 ± 1.94 years with a total of 9 participants with 4 males and 5 females. It can be observed that in both the groups, the rate of canine retraction at three different time interval was highly significant (p<0.001) but minimal differences was seen between LPRP and MOP groups which was not statistically significant.</p><p> </p><p>CONCLUSION: This study demonstrated that both MOP and LPRP showed accelerated tooth movement over the course of two months ,while the difference between the two groups was not statistically significant. Future studies to further validate these findings with larger sample sizes are recommended.</p><p> </p>