From daily burden to scheduled protection: the “vaccine-like” shift in hypertension
Global hypertension control remains stagnant due to the fragility of daily medication adherence rather than a lack of effective drugs. Long-acting siRNA therapies offer a "vaccine-like" paradigm shift, transferring responsibility from the patient's daily memory to the health system's reliability. This approach introduces "pharmacological moral hazard," where patients may neglect lifestyle modifications under a false sense of total security.
Authors
- Lucas Maciel de Almeida Corrêa (ORCID: https://orcid.org/0009-0003-7247-4950)
- Gabriel Costa de Santana (ORCID: https://orcid.org/0009-0009-8889-3117)
- LM Brandão (ORCID: https://orcid.org/0009-0000-3774-604X)
- Letícia Esteves Dante (ORCID: https://orcid.org/0009-0005-3775-3350)
- Gabriel Rian Mazur (ORCID: https://orcid.org/0009-0001-5368-2901)
- Clara Belo Gamon Santiago (ORCID: https://orcid.org/0009-0002-4791-4451)
- Alexandre de Assis Barbosa (ORCID: https://orcid.org/0009-0002-3274-2319)
Institutions
- Faculdade de Medicina de São José do Rio Preto (BR)
- Pontifícia Universidade Católica do Paraná (BR)
- Universidade Estadual de Mato Grosso do Sul (BR)
- Centro Universitário do Norte (BR)
- Universidade Salvador (BR)
Publication Details
- Journal
- Journal of Human Hypertension
- Published
- 2026-04-25
- DOI
- https://doi.org/10.1038/s41371-026-01149-2
- Primary Topic
- Sodium Intake and Health
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Coordenação de Aperfeiçoamento de Pessoal de Nível Superior