Isotope In-Phase/Opposite-Phase-Edited 2D <sup>1</sup> H– <sup>1</sup> H ( <sup>12</sup> C/ <sup>13</sup> C) TOCSY and Complementary 1D <sup>1</sup> H Selective NMR Experiments for Carbon Tracing in Complex Samples
H IP/OP TOCSY simultaneously identified pre-existing and newly synthesized molecules, while 1D experiments provide quantitative support, offering a sensitive framework to study carbon dynamics, preservation, and transformation in complex in vivo and ex vivo processes.
Authors
- Falko Busse
- Myrna J. Simpson (ORCID: https://orcid.org/0000-0002-8084-411X)
- Amy Jenne (ORCID: https://orcid.org/0000-0002-1633-3649)
- Emily Jaeger
- W. Wesley Dowd (ORCID: https://orcid.org/0000-0002-8153-1983)
- Agnes Haber
- Katelyn Downey (ORCID: https://orcid.org/0000-0001-5405-7449)
- William W. Wolff
- Daniel H. Lysak (ORCID: https://orcid.org/0000-0002-4294-6094)
- Wolfgang Bermel
- André J. Simpson (ORCID: https://orcid.org/0000-0002-8247-5450)
- Kiera Ronda
- Jacob Pellizzari
- Peter M. Costa
- Katrina Steiner
- Owen Vander Meulen
- Venita Busse
- Caroline Terry
- Sequoia Thompson
Institutions
- University of Toronto (CA)
- Bruker (United States) (US)
- Bruker (Switzerland) (CH)
- Washington State University (US)
Publication Details
- Journal
- Analytical Chemistry
- Published
- 2026-04-25
- DOI
- https://doi.org/10.1021/acs.analchem.6c00593
- Primary Topic
- Metabolomics and Mass Spectrometry Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Canada Foundation for Innovation
- Krembil Foundation
- Health Canada
- Natural Sciences and Engineering Research Council of Canada
- Ontario Ministry of Research and Innovation