CHOLEBLADEUS: long-term results of endoscopic ultrasound-guided gallbladder versus bile duct drainage of malignant biliary obstruction after failed ERCP: a propensity-matched study.
BACKGROUND: Endoscopic ultrasound (EUS)-guided gallbladder drainage (EUS-GBD) is emerging as an alternative to choledochoduodenostomy (EUS-CDS) for malignant distal biliary obstruction (MDBO) after failed endoscopic retrograde cholangiopancreatography (ERCP). Comparative data on long-term patency are limited. METHODS: This retrospective international study analyzed two historical cohorts of patients who underwent EUS-GBD or EUS-CDS for MDBO after failed ERCP between March 2017 and May 2024. Eligible patients were aged ≥18 years with at least 6 months' follow-up or confirmed death. The primary outcome, after 1 : 1 propensity score matching, was 12-month biliary patency. Secondary outcomes included technical and clinical success, adverse events (AEs), reintervention rates, and overall survival. RESULTS: In patients with MDBO after failed ERCP, EUS-GBD achieved higher 12-month biliary patency than EUS-CDS, with comparable rates of technical and clinical success, morbidity, reintervention, and overall survival.
Authors
- Jocelyn Privat
- Sergio Bazaga (ORCID: https://orcid.org/0000-0002-2984-5176)
- M Camus
- Frédérick Moryoussef
- Carme Loras (ORCID: https://orcid.org/0000-0002-4035-3316)
- Jérémie Albouys
- M Schaefer
- Diane Lorenzo (ORCID: https://orcid.org/0000-0002-3729-8416)
- Jules Daniel
- Nicolas Williet (ORCID: https://orcid.org/0000-0002-7296-5464)
- T Wallenhorst
- Salomé Ouazana (ORCID: https://orcid.org/0000-0001-8035-5976)
- Alban Benezech (ORCID: https://orcid.org/0000-0002-6984-9366)
- Antoine Debourdeau (ORCID: https://orcid.org/0000-0003-3785-6948)
- Romain Gérard (ORCID: https://orcid.org/0000-0003-4674-7444)
- Romain Legros
- Jean‐François Bourgaux
- Júlia Escuer-Turu
- L Caillo
- Jeremie Jacques
- Joan B Gornals
- Pierre Mayer
- Sarah Leblanc
- Marie Goudot
- Bertrand Napoleon
Institutions
- Hôpital Beaujon (FR)
- Bellvitge University Hospital (ES)
- Centre Hospitalier Universitaire de Lille (FR)
- Université Rennes 2 (FR)
- Sorbonne Université (FR)
- Institut d'Investigació Biomédica de Bellvitge (ES)
- Lille’s Cardiology Hospital (FR)
- Institut Européen De La Qualité Totale (FR)
- Centre Hospitalier Universitaire de Montpellier (FR)
- Assistance Publique – Hôpitaux de Paris (FR)
- Centre Hospitalier Régional et Universitaire de Nancy (FR)
- Hôpital Saint-Antoine (FR)
- Centre Hospitalier Universitaire de Nîmes (FR)
- Centre Hospitalier Intercommunal de Poissy (FR)
- Hospital General de Granollers (ES)
- Institute Cancer De La Loire Lucien Neuwirth (FR)
- Laboratoire Informatique d'Avignon (FR)
- Hôpital Privé Jean Mermo (FR)
- Mútua Terrassa (ES)
- Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (ES)
- Centre de Recherche Saint-Antoine (FR)
- Centre Hospitalier Universitaire de Rennes (FR)
- Hôpital Civil, Strasbourg (FR)
- Université de Rennes (FR)
- Université de Limoges (FR)
- Université de Strasbourg (FR)
Publication Details
- Journal
- PubMed
- Published
- 2026-04-24
- DOI
- https://doi.org/10.1055/a-2837-9342
- Primary Topic
- Gallbladder and Bile Duct Disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00