Antibiotic treatment reveals the contributions of the gut microbiome to CLN2 disease in the central and enteric nervous system
mice. These findings suggest that intestinal and ENS pathology is primarily driven by TPP1-deficiency rather than changes in the gut microbiome. Indeed, these alterations to the gut microbiome may occur secondary to the impact of CLN2 disease upon the bowel.
Authors
- Agnieszka Nowacka (ORCID: https://orcid.org/0000-0002-5848-8788)
- Letitia L. Williams
- Marta Celorrio (ORCID: https://orcid.org/0000-0002-5722-5783)
- Stuart Howard Friess (ORCID: https://orcid.org/0000-0002-5854-5092)
- Elizabeth M. Eultgen
- Jonathan D. Cooper (ORCID: https://orcid.org/0000-0003-1339-4750)
- Bartlomiej Olszowy
- Robert O. Heuckeroth (ORCID: https://orcid.org/0000-0002-3282-1765)
- Ewa Ziólkowska
- Paris Nix
Institutions
- Bydgoszcz University of Science and Technology (PL)
- Children's Hospital of Philadelphia (US)
- Washington University in St. Louis (US)
- Nicolaus Copernicus University (PL)
- AGH University of Krakow (PL)
- University of Pennsylvania (US)
Publication Details
- Journal
- Scientific Reports
- Published
- 2026-04-25
- DOI
- https://doi.org/10.1038/s41598-026-49850-z
- Primary Topic
- Lysosomal Storage Disorders Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Institutes of Health
- National Institute of Neurological Disorders and Stroke