Association of the TGF-beta1 polymorphism with primary open-angle glaucoma: a case-control study

Background: Primary open-angle glaucoma (POAG) is characterized by increased resistance to aqueous humor outflow. Transforming growth factor beta-1 (TGF-beta1) contributes to this resistance by promoting synthesis and remodeling of the extracellular matrix in the trabecular meshwork, thereby reducing outflow facility. This study aimed to investigate the association between the TGF-beta1 gene polymorphism at position -800 G>A (rs1800468) and POAG in patients from Khorasan Razavi Province, Iran. Methods: In this case-control study, patients with POAG referred to Khatam-al-Anbia Hospital were enrolled as the case group, and age-matched healthy individuals served as controls. Demographic and clinical data of participants were recorded, collecting 5 mL of whole blood from each individual. DNA was extracted, genotyping the TGF-beta1 -800 G>A polymorphism using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). Results: > 0.05). Conclusions: The TGF-beta1 -800 G>A polymorphism does not appear to play a significant role in POAG development in this population. Inheritance of the mutant A allele is not a risk factor for POAG in northeastern Iran.