Effect of GLP‐1 Receptor Agonists on Post‐Ablation Atrial Fibrillation Recurrence: A Meta‑Analysis
BACKGROUND: Among patients undergoing catheter ablation for atrial fibrillation (AF), it remains uncertain whether peri- or post-ablation use of glucagon-like peptide-1 receptor agonists (GLP-1 RAs) reduces AF recurrence. OBJECTIVES: We conducted a meta-analysis of observational studies and randomized controlled trials comparing GLP-1 RA therapy versus no GLP-1 RA use on AF recurrence following ablation. METHODS: . Time-to-event outcomes were synthesized using reconstructed individual patient data from Kaplan-Meier curves. RESULTS: = 46.9%). CONCLUSION: GLP-1 RA therapy was associated with reduced AF recurrence after ablation, but methodological limitations warrant cautious interpretation. Prospective randomized trials are needed to confirm this potential benefit.
Authors
- Mohamed Abuelazm (ORCID: https://orcid.org/0000-0002-2514-0689)
- Mohammed Mhanna (ORCID: https://orcid.org/0000-0003-1443-7177)
- Ibrahim Gowaily (ORCID: https://orcid.org/0000-0002-5045-6810)
- Ameer Awashra (ORCID: https://orcid.org/0009-0002-5122-8200)
- Ahmed Mohamed (ORCID: https://orcid.org/0009-0004-3320-7662)
- Mohamed S. Elgendy (ORCID: https://orcid.org/0000-0003-3080-2875)
- Ahmed Elbataa (ORCID: https://orcid.org/0009-0009-7065-381X)
- Ahmed Emara
- Abdalhakim Shubietah
- Emmanuel Olumuyide
- Mohammad Alqudah (ORCID: https://orcid.org/0000-0001-6645-1830)
- Mohamed R. Murad
Institutions
- Creighton University (US)
- University of Iowa (US)
- An-Najah National University (PS)
- Al-Azhar University (EG)
- Tanta University (EG)
- Twin Cities Orthopedics (US)
- Advocate Illinois Masonic Medical Center (US)
- Yarmouk University (JO)
Publication Details
- Journal
- Pacing and Clinical Electrophysiology
- Published
- 2026-04-25
- DOI
- https://doi.org/10.1111/pace.70262
- Primary Topic
- Atrial Fibrillation Management and Outcomes
- Type
- article
- Field-Weighted Citation Impact
- 0.00