Synthesis and Evaluation of a PET Radiotracer [ <sup>18</sup> F]LY3000328 Selectively Targeting the Cysteine Protease Cathepsin S
F]LY3000328 may serve as a useful starting scaffold for further optimization of physicochemical and pharmacokinetic properties toward Cat S-targeted PET imaging of neuroinflammation in AD and potentially other neurodegenerative disorders.
Authors
- Yulong Xu (ORCID: https://orcid.org/0000-0001-9024-7311)
- Changning Wang (ORCID: https://orcid.org/0000-0002-2076-4193)
- Yongle Wang
- Can Zhang (ORCID: https://orcid.org/0000-0002-4340-5118)
- Yue Wang (ORCID: https://orcid.org/0000-0003-0098-5359)
- H Y Yang
- Yafei Huang (ORCID: https://orcid.org/0009-0000-0674-7357)
- Hua Cheng (ORCID: https://orcid.org/0009-0003-7134-0344)
Institutions
- Brigham and Women's Hospital (US)
- Harvard University (US)
- Massachusetts General Hospital (US)
- MaineGeneral Medical Center (US)
- Athinoula A. Martinos Center for Biomedical Imaging (US)
Publication Details
- Journal
- ACS Chemical Neuroscience
- Published
- 2026-04-25
- DOI
- https://doi.org/10.1021/acschemneuro.6c00167
- Primary Topic
- Protease and Inhibitor Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- NIH Office of the Director