Lymphocyte Micronucleus Formation Is Driven by Inflammation‐Induced Oxidative <scp>DNA</scp> Damage in Oesophageal Cancer Development
or DCA, suggesting altered oxidative stress responses. MN% also associated with plasma 8-OHdG, IL-8 and 2'3'-cGAMP, and with reduced oesophageal tissue IκB, indicating activation of oxidative and cGAS-STING/NF-κB signalling. These findings highlight systemic aneugenic and oxidative stress processes that contribute to lymphocyte MN formation in OAC and suggest that MN% may serve as a minimally invasive indicator of inflammation-linked genomic instability. Further investigation is needed to determine its relevance to OAC progression.
Authors
- Gareth Jenkins (ORCID: https://orcid.org/0000-0002-5437-8389)
- Owen Bodger (ORCID: https://orcid.org/0000-0002-4022-9964)
- François Virard (ORCID: https://orcid.org/0000-0001-7570-1088)
- Lisa Williams (ORCID: https://orcid.org/0000-0003-0250-5902)
- Hasan Haboubi (ORCID: https://orcid.org/0000-0001-7324-7889)
- Kathryn Munn
- Hamsa Naser
- Sarah Gwynne
- Rachel Lawrence
- Kate Hurlow
- Jiri Zavadil
- Laura E. Thomas
- Ume‐Kulsoom Shah
- Shareen Doak
Institutions
- Université Claude Bernard Lyon 1 (FR)
- Centre National de la Recherche Scientifique (FR)
- Swansea Bay University Health Board (GB)
- Cardiff and Vale University Health Board (GB)
- Inserm (FR)
- Queen Mary University of London (GB)
- Swansea University (GB)
- Centre Léon Bérard (FR)
- Centre de Recherche en Cancérologie de Lyon (FR)
- Centre international de recherche sur le cancer (FR)
Publication Details
- Journal
- International Journal of Cancer
- Published
- 2026-04-25
- DOI
- https://doi.org/10.1002/ijc.70494
- Primary Topic
- Esophageal Cancer Research and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Cancer Research Wales
- Swansea University