EB1010, a putative Christensenellaceae-derived microbial peptide, exhibits anti-inflammatory activity and therapeutic potential in ulcerative colitis
studies demonstrated that oral administration effectively reversed inflammation in both trinitrobenzene sulfonic acid- (TNBS)-induced rat and DSS-induced mouse models of colitis. Caco-2 transport assays revealed minimal peptide permeability, consistent with pharmacokinetic (PK) data showing no plasma detection in orally treated rats, supporting a local intestinal mode of action. EB1010 was well tolerated in a 4-week rat toxicology study, with no adverse effect observed at doses up to 1.5 mg/kg/d by intravenous administration. These findings position EB1010 as a safe, locally acting, microbiota-derived peptide with potential therapeutic applications.
Authors
- Christophe Bonny (ORCID: https://orcid.org/0009-0006-8890-0290)
- Cendrine Nicoletti (ORCID: https://orcid.org/0000-0002-0086-6707)
- Antonietta Cultrone (ORCID: https://orcid.org/0009-0000-4706-9599)
- Camille Baudesson de Chanville
- Camille Mailhac
- Eric Di Pasquale (ORCID: https://orcid.org/0000-0003-4088-8238)
- Souphalone Luangsay
- Laurent Chêne
- Francesco Strozzi (ORCID: https://orcid.org/0000-0002-6845-6982)
- William Farin (ORCID: https://orcid.org/0000-0002-4128-8923)
- Marc Maresca (ORCID: https://orcid.org/0000-0002-3585-4765)
- Laureen Bardouillet
- Grégoire Chevalier (ORCID: https://orcid.org/0000-0003-4698-1206)
- Hélène Pfister
- Jessica Quessel
- Philippe Rinaudo
- Valentine Thomas (ORCID: https://orcid.org/0009-0006-9530-5043)
- Stephanie Blum
- Hélène Pereira
- Maria L. Orsini Delgado (ORCID: https://orcid.org/0000-0003-4655-1695)
- Hélène Toussaint
Institutions
- Institut de Neurophysiopathologie (FR)
- Drug Discovery Laboratory (Norway) (NO)
- Centrale Méditerranée (FR)
- Nestlé (France) (FR)
Publication Details
- Journal
- Gut Microbes
- Published
- 2026-04-25
- DOI
- https://doi.org/10.1080/19490976.2026.2662547
- Primary Topic
- Probiotics and Fermented Foods
- Type
- article
- Field-Weighted Citation Impact
- 0.00