Idiopathic Intracranial Hypertension Associated With Therapeutic-Dose <i>N</i> -Acetylcysteine in a 6-Year-Old Boy: A Case Report
O and normal cerebrospinal fluid composition. The patient had been treated with oral NAC 200 mg twice daily for 4 weeks before symptom onset. Acetazolamide and topiramate were started with no improvement; symptoms and papilledema improved rapidly within 24 hours of NAC discontinuation. The patient remained asymptomatic at 6 months of follow-up. This case suggests a possible association between therapeutic-dose NAC and intracranial hypertension. Clinicians should consider medication-induced PTCS in children who present with new-onset headaches and papilledema. Further pharmacovigilance and reporting are warranted.
Authors
- Ali Aghajani (ORCID: https://orcid.org/0000-0002-7790-6033)
- Farnaz Bahrami‐Samani (ORCID: https://orcid.org/0009-0003-2356-786X)
- Mohammadreza Zolfaghari
- Afshin Najafi
Institutions
- Isfahan University of Medical Sciences (IR)
Publication Details
- Journal
- Journal of Child Neurology
- Published
- 2026-04-25
- DOI
- https://doi.org/10.1177/08830738261427554
- Primary Topic
- Cerebral Venous Sinus Thrombosis
- Type
- article
- Field-Weighted Citation Impact
- 0.00