Idiopathic Intracranial Hypertension Associated With Therapeutic-Dose <i>N</i> -Acetylcysteine in a 6-Year-Old Boy: A Case Report

O and normal cerebrospinal fluid composition. The patient had been treated with oral NAC 200 mg twice daily for 4 weeks before symptom onset. Acetazolamide and topiramate were started with no improvement; symptoms and papilledema improved rapidly within 24 hours of NAC discontinuation. The patient remained asymptomatic at 6 months of follow-up. This case suggests a possible association between therapeutic-dose NAC and intracranial hypertension. Clinicians should consider medication-induced PTCS in children who present with new-onset headaches and papilledema. Further pharmacovigilance and reporting are warranted.

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Publication Details

Journal
Journal of Child Neurology
Published
2026-04-25
DOI
https://doi.org/10.1177/08830738261427554
Primary Topic
Cerebral Venous Sinus Thrombosis
Type
article
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article

Idiopathic Intracranial Hypertension Associated With Therapeutic-Dose N -Acetylcysteine in a 6-Year-Old Boy: A Case Report

Ali Aghajani, Farnaz Bahrami‐Samani, Mohammadreza Zolfaghari, Afshin Najafi
Journal of Child Neurology
Cerebral Venous Sinus Thrombosis
article

Idiopathic Intracranial Hypertension Associated With Therapeutic-Dose N -Acetylcysteine in a 6-Year-Old Boy: A Case Report

Ali Aghajani, Farnaz Bahrami‐Samani, Mohammadreza Zolfaghari, Afshin Najafi
article en

Abstract

O and normal cerebrospinal fluid composition. The patient had been treated with oral NAC 200 mg twice daily for 4 weeks before symptom onset. Acetazolamide and topiramate were started with no improvement; symptoms and papilledema improved rapidly within 24 hours of NAC discontinuation. The patient remained asymptomatic at 6 months of follow-up. This case suggests a possible association between therapeutic-dose NAC and intracranial hypertension. Clinicians should consider medication-induced PTCS in children who present with new-onset headaches and papilledema. Further pharmacovigilance and reporting are warranted.

Journal of Child Neurology
Isfahan University of Medical Sciences (IR)
Good health and well-being
Openalex Percentile: Top 5%
Cerebral Venous Sinus Thrombosis
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Idiopathic Intracranial Hypertension Associated With Therapeutic-Dose <i>N</i> -Acetylcysteine in a 6-Year-Old Boy: A Case Report — Ali Aghajani, Farnaz Bahrami‐Samani, et al. · Journal of Child Neurology (2026) | TGRS Research Map | TGRS