Cyclization, amino acid coupling, docking-based virtual screening and SAR: showing a strategy of the structural modification for salvianic acid A

AIM: Providing diverse modification remains to be a strategy for salvianic acid A. MATERIALS AND METHODS: ), and evaluated their effects on platelet aggregation, thrombus formation, and determine serum levels of P-selectin and GPIIb/IIIa in male SD rats. RESULTS: effectively decreased the serum P-selectin and GPIIb/IIIa level. CONCLUSION: was particularly superior and could be a promising candidate for the afterward development. Additionally, the benefits of the 19 derivatives were associated with the serum level of P-selectin and GPIIb/IIIa.