Mitochondrial fission mediates an evolutionarily conserved antibacterial defense response
suppressed antibacterial mitochondrial fission, but restoring this response by inhibiting mitochondrial fusion-promoting histone deacetylase 6 (HDAC6) reactivated lipid droplet production and bacterial clearance. Therefore, we propose that mitochondrial fission is an ancient host defense pathway that can be exploited for anti-infective design.
Authors
- Marta Bosch (ORCID: https://orcid.org/0000-0003-3934-6781)
- Ronan Kapétanovic (ORCID: https://orcid.org/0000-0002-2908-1014)
- Kaustav Das Gupta (ORCID: https://orcid.org/0000-0001-6430-1660)
- Steven Zuryn (ORCID: https://orcid.org/0000-0002-3551-6790)
- Claudia J. Stocks (ORCID: https://orcid.org/0000-0001-6120-2851)
- Robert C. Reid (ORCID: https://orcid.org/0000-0002-0829-239X)
- Matthew J. Sweet (ORCID: https://orcid.org/0000-0002-0406-8139)
- Robert G. Parton (ORCID: https://orcid.org/0000-0002-7494-5248)
- Kate Schroder (ORCID: https://orcid.org/0000-0001-9261-3805)
- Arnaud Ahier (ORCID: https://orcid.org/0000-0002-9999-3887)
- Charles Ferguson
- Nilesh J. Bokil (ORCID: https://orcid.org/0000-0003-3202-9249)
- Zeinab G. Khalil (ORCID: https://orcid.org/0000-0002-9285-1720)
- Syeda Farhana Afroz (ORCID: https://orcid.org/0000-0001-6066-3445)
- Grace Lawrence (ORCID: https://orcid.org/0000-0001-9764-1194)
- J LIU (ORCID: https://orcid.org/0009-0004-3174-152X)
- Divya Ramnath (ORCID: https://orcid.org/0000-0002-1935-9043)
- David P. Fairlie (ORCID: https://orcid.org/0000-0002-7856-8566)
- Albert Pol (ORCID: https://orcid.org/0000-0002-1750-1085)
- Ina Kirmes
- Mark A. Schembri (ORCID: https://orcid.org/0000-0003-4863-9260)
- Melanie R. Shakespear (ORCID: https://orcid.org/0000-0002-9517-0699)
- Karl A. Hansford (ORCID: https://orcid.org/0000-0003-2535-9071)
- Antje Blumenthal (ORCID: https://orcid.org/0000-0003-3673-7015)
- Philip M. Hansbro (ORCID: https://orcid.org/0000-0002-4741-3035)
- Gabriele Matthias (ORCID: https://orcid.org/0009-0008-7585-8243)
- Patrick Matthias (ORCID: https://orcid.org/0000-0002-3927-1452)
- Stephan Nothjunge (ORCID: https://orcid.org/0000-0003-4845-3765)
- Karoline D. Raven (ORCID: https://orcid.org/0000-0002-7579-9721)
- ME Cooper
- Bernhard Keller
- Jordan D. Atkinson
- Tam T. K. Nguyen
- James E. B. Curson (ORCID: https://orcid.org/0000-0002-4672-3357)
Institutions
- Université de Tours (FR)
- University of Technology Sydney (AU)
- Institució Catalana de Recerca i Estudis Avançats (ES)
- The University of Queensland (AU)
- University of Basel (CH)
- University of Cambridge (GB)
- Park Centre for Mental Health (AU)
- Centenary Institute (AU)
- Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement (FR)
- Friedrich Miescher Institute (CH)
- Infectiologie et santé publique (FR)
- Consorci Institut D'Investigacions Biomediques August Pi I Sunyer (ES)
- Universitat de Barcelona (ES)
- University of Newcastle Australia (AU)
Publication Details
- Journal
- Science Immunology
- Published
- 2026-04-24
- DOI
- https://doi.org/10.1126/sciimmunol.aed2623
- Primary Topic
- Mitochondrial Function and Pathology
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Novartis Foundation
- Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung
- University of Queensland
- European Research Council
- Australian Research Council