Diminished plasma levels of GPIb-α predict mortality in a prospective ARDS cohort
Introduction: to correlate our measurements with the clinical presentation of ARDS. Methods: plasma levels. Multivariate Cox analysis was performed to identify risk factors for mortality. Results: levels (0-130 ng/mL) had a mortality rate of 53%; in patients with higher levels (341-850 ng/mL), the mortality rate was 10%. Discussion: plasma levels were associated with a higher mortality rate in ARDS. Diminished plasma levels might point to a higher consumption of the receptor, with an unfavorable effect on overall survival. Trial registration: EUDRA-CT: 2016-003168-37. Registered on 12/04/2017. ClinicalTrials.gov: NCT03111212. Registered on 04/06/2017.
Authors
- Valbona Mirakaj (ORCID: https://orcid.org/0000-0002-6907-6455)
- Andreas Margraf (ORCID: https://orcid.org/0000-0002-6539-6478)
- Lina María Serna-Higuita (ORCID: https://orcid.org/0000-0001-5182-8295)
- Michael Koeppen (ORCID: https://orcid.org/0000-0002-5002-1286)
- Claudia Eggstein
- Karina Althaus (ORCID: https://orcid.org/0000-0002-7279-4861)
- Christina Fodi
- Andreas Körner
- Alice Bernard (ORCID: https://orcid.org/0000-0001-6056-2599)
- A Zarbock
- Tamam Bakchoul
- Robin Vöhringer
- Helene Haeberle
- Peter Rosenberger
Institutions
- Goethe University Frankfurt (DE)
- Institute for Transfusion Medicine (US)
- Intensive Care Society (GB)
- University Hospital Münster (DE)
- University Hospital Frankfurt (DE)
- Institute for Medical Informatics and Biostatistics (CH)
Publication Details
- Journal
- Frontiers in Medicine
- Published
- 2026-04-24
- DOI
- https://doi.org/10.3389/fmed.2026.1711751
- Primary Topic
- Platelet Disorders and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00