An astragalus polysaccharide-loaded hydrogel dressing enhances diabetic wound healing via dual-mode electrical stimulation
assays demonstrated that the DES-PGSA dressing markedly promoted wound healing in diabetic rats compared with other groups, which could be mainly ascribed to the sustainable and stable electrical stimulation. Mechanistically, APS provides anti-inflammatory and pro-healing effects, while the electrical stimulation strengthens the cytoskeleton polarization which enabling the regulation of the direction of wound healing. Collectively, the functional wound dressing developed in this study provides a promising candidate for the treatment of complex wounds like diabetic wounds.
Authors
- Guangbo Ji (ORCID: https://orcid.org/0009-0000-7079-8896)
- Xiaoqing Huo
- Qiang Zhao (ORCID: https://orcid.org/0000-0003-4656-6002)
- Zhiyi Wu (ORCID: https://orcid.org/0000-0002-3215-0092)
- Tian Tang
- Zheng Chen (ORCID: https://orcid.org/0000-0001-8898-1031)
- Jizhong Deng
- Fenghe Li (ORCID: https://orcid.org/0000-0003-3965-8152)
- Hao Tian
- Bin Liu (ORCID: https://orcid.org/0009-0001-8024-4712)
Institutions
- Guizhou University (CN)
- Chinese Academy of Sciences (CN)
- Nankai University (CN)
- The Affiliated Yongchuan Hospital of Chongqing Medical University (CN)
- Beijing Institute of Nanoenergy and Nanosystems (CN)
- National Center for Nanoscience and Technology (CN)
- Beihang University (CN)
- Chongqing Medical University (CN)
Publication Details
- Journal
- Bioactive Materials
- Published
- 2026-04-24
- DOI
- https://doi.org/10.1016/j.bioactmat.2026.04.029
- Primary Topic
- Wound Healing and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Chongqing Medical University
- Natural Science Foundation of Chongqing