Ruthenium-Catalyzed Synthesis of S,C-Sulfonium Ylides
Herein, we present an unprecedented ruthenium-catalyzed transylidation reaction between sulfides and iodonium ylides, enabling the synthesis of S,C-sulfonium ylides under mild conditions. This approach expands the scope of sulfonium ylide chemistry with broad substrate compatibility and good functional group tolerance. Additionally, scaled-up synthesis and transformation experiments further highlight its synthetic utility. It offers an efficient route to structurally diverse sulfonium ylides.
Authors
- Xiaowei Wu (ORCID: https://orcid.org/0000-0001-7248-9149)
- Zhiyue He
- Yaxi Liu (ORCID: https://orcid.org/0000-0002-3261-829X)
- Qionglin Ge
Institutions
- Nanjing University of Chinese Medicine (CN)
- Chinese Academy of Sciences (CN)
- Shanghai Institute of Materia Medica (CN)
- Drug Discovery Laboratory (Norway) (NO)
Publication Details
- Journal
- The Journal of Organic Chemistry
- Published
- 2026-04-24
- DOI
- https://doi.org/10.1021/acs.joc.6c00015
- Primary Topic
- Catalytic C–H Functionalization Methods
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Zhongshan Science and Technology Bureau