Electronic Structure-Engineered Vanadium Carbide MXene Nanocatalyst Enables Multimodal Reactive Species Scavenging for Stem Cell Regulation
C demonstrates high catalytic stability over multiple cycles and preserves endogenous defense pathways without inducing cytotoxicity. Under oxidative stress, the nanocatalyst protects mesenchymal stem cells by suppressing reactive species-induced cell damage and restoring adhesion, proliferation, and migratory capacity while simultaneously promoting osteogenic differentiation. This study establishes a robust strategy for electronic-structure engineering of vanadium-based MXene biocatalysts and highlights their potential as high-performance platforms for stem cell protection and redox microenvironment regulation.
Authors
- Jinzheng Liu
- Zhe Hao (ORCID: https://orcid.org/0009-0003-8066-3815)
- F S Zhang
- Libing Zhang (ORCID: https://orcid.org/0000-0002-7983-7326)
- Huan Guo
- Ziyan Yu
- Shou Liu
- Ruizhong Zhang
- Xiyan Li (ORCID: https://orcid.org/0000-0003-1792-7358)
Institutions
- Tianjin University (CN)
- Nankai University (CN)
- Tianjin Academy of Fine Arts (CN)
- Tianjin Renai College
Publication Details
- Journal
- Langmuir
- Published
- 2026-04-24
- DOI
- https://doi.org/10.1021/acs.langmuir.6c00237
- Primary Topic
- MXene and MAX Phase Materials
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China