Orbitofrontal PV interneurons modulate social interaction via default mode network dynamics

Social interactions are critical for mental health and are frequently disrupted in neuropsychiatric disorders. Clinical data suggest a link between dysfunction of the default mode network (DMN) and social impairment. To advance our understanding of the neurobiological mechanisms underlying social dysfunction, we back-translate these clinical findings into a preclinical setup, demonstrating that impaired DMN connectivity - achieved through activation of Parvalbumin interneurons in the orbitofrontal cortex (OFC) reduces normal social behaviour.