Multilayered analysis of cisplatin resistance mechanisms in bladder cancer: from the cell membrane to organelles
, and clinical evidence versus those that remain primarily exploratory. By viewing cisplatin resistance in BCa as an integrated and dynamic network spanning cellular compartments, this multilayered synthesis aims to refine current mechanistic concepts and to provide a rationale for biomarker development and combination strategies designed to prevent or overcome cisplatin resistance.
Authors
- Long Cheng (ORCID: https://orcid.org/0000-0002-7084-5821)
- Chengyu You (ORCID: https://orcid.org/0000-0002-7692-9401)
- Yidong Liu
- Weiguang Yang (ORCID: https://orcid.org/0000-0003-3324-4346)
- Longtu Ma
- Yan Tao
- Xi Xiao
- Zhilong Dong
Institutions
- Qingdao University (CN)
- Lanzhou University Second Hospital (CN)
- Taian City Central Hospital (CN)
- Lanzhou University (CN)
Publication Details
- Journal
- PeerJ
- Published
- 2026-04-24
- DOI
- https://doi.org/10.7717/peerj.21148
- Primary Topic
- Ferroptosis and cancer prognosis
- Type
- article
- Field-Weighted Citation Impact
- 0.00