Influence of Tramadol on the Intravenous Pharmacokinetics of Dipyrone Active Metabolites in Dogs
differed significantly. Tramadol and its metabolites were also described. The pharmacokinetic interaction between dipyrone and tramadol increased systemic exposure (AUC) of AA and inhibited the conversion of tramadol to M1, without direct changes in the severe adverse effects associated with MAA. Further studies involving nociceptive stimuli and multiple-dose regimens are needed to assess clinical relevance.
Authors
- Naftáli Silva Fernandes (ORCID: https://orcid.org/0000-0002-8513-1661)
- Kathryn Nóbrega Arcoverde (ORCID: https://orcid.org/0000-0002-5409-7421)
- Valéria Veras de Paula (ORCID: https://orcid.org/0000-0003-4292-4861)
- Yanna Deysi Bandeira Passos (ORCID: https://orcid.org/0009-0006-4497-9830)
- Andressa Nunes Mouta (ORCID: https://orcid.org/0000-0003-0319-2696)
- Robson dos Anjos Honorato (ORCID: https://orcid.org/0000-0002-6640-1363)
- Gabriel Araújo‐Silva (ORCID: https://orcid.org/0000-0002-9073-1995)
- Caio Vinícius Almeida de Oliveira
- Glícia Cavalcante Mesquita
Institutions
- Centro Universitário Una (BR)
- Universidade Estadual do Amapá (BR)
- Universidade Federal Rural do Semi-Árido (BR)
Publication Details
- Journal
- Journal of Veterinary Pharmacology and Therapeutics
- Published
- 2026-04-24
- DOI
- https://doi.org/10.1111/jvp.70073
- Primary Topic
- Veterinary Pharmacology and Anesthesia
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Conselho Nacional de Desenvolvimento Científico e Tecnológico