Longitudinal localization of leukaemic stem cells between the metaphysis and central marrow governs their behaviour
stromal cells and the surrounding matrix impaired LSC recruitment. These effects arise from the CXCL12-DPP4-GPC3 axis, in which DPP4 truncates and inactivates CXCL12, whereas stromal GPC3 restrains DPP4 activity. Modulating this axis disrupts niche protection and enhances therapeutic vulnerability in AML.
Authors
- Ruochen Dong (ORCID: https://orcid.org/0009-0002-6529-7194)
- Ravi Nistala (ORCID: https://orcid.org/0000-0001-9577-8074)
- Richard Hammer (ORCID: https://orcid.org/0000-0002-7173-9414)
- Linheng Li (ORCID: https://orcid.org/0000-0001-9963-430X)
- Xiaduo Meng (ORCID: https://orcid.org/0009-0005-4747-0426)
- Yi Pan (ORCID: https://orcid.org/0000-0002-7381-9776)
- Xunlei Kang (ORCID: https://orcid.org/0000-0003-1853-1881)
- C X Wang
- Xi Kang
- Wenxuan Zhou
Institutions
- Stowers Institute for Medical Research (US)
- University of Missouri Health System (US)
- Precision for Medicine (United States) (US)
- University of Kansas Medical Center (US)
- University of Missouri (US)
Publication Details
- Journal
- Nature Cell Biology
- Published
- 2026-04-24
- DOI
- https://doi.org/10.1038/s41556-026-01939-3
- Primary Topic
- Acute Myeloid Leukemia Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- American Cancer Society
- National Cancer Institute