Neonatal testosterone exposure modulates exploration and object avoidance without exacerbating autism-like behavior in Shank3b-deficient mice
mice self-groomed threefold longer, buried 31% fewer marbles, and spent 37% less time by vertical exploration than wild-type mice. Neonatal exposure to testosterone seems to affect object avoidance and exploration, rather than ASD-like behavior. Early testosterone exposure or its synergistic effects with sex and genetic predisposition on the ASD-like phenotype later in life seem to be limited.
Authors
- Daniela Ostatníková (ORCID: https://orcid.org/0000-0002-4960-5057)
- Veronika Borbélyová (ORCID: https://orcid.org/0000-0001-7014-9626)
- Emese Renczés (ORCID: https://orcid.org/0000-0003-2667-636X)
- Johan Filo
- Peter Celec (ORCID: https://orcid.org/0000-0001-5883-3580)
- Jakub Szabó (ORCID: https://orcid.org/0000-0002-6085-1291)
- Petronela Sušienková
Institutions
- Comenius University Bratislava (SK)
Publication Details
- Journal
- Hormones and Behavior
- Published
- 2026-04-24
- DOI
- https://doi.org/10.1016/j.yhbeh.2026.105935
- Primary Topic
- Autism Spectrum Disorder Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Ministerstvo školstva, vedy, výskumu a športu Slovenskej republiky
- Agentúra na Podporu Výskumu a Vývoja