Preconception metabolic-bariatric surgery and child health outcomes: Identification and cohort profile of the POSIT study protocol
), and year of delivery. Following matching, the MBS group had similar socioeconomic and health disparities as the pre-surgery control group, and both were worse than pre-pregnancy control group. Pregestational maternal comorbidity index improved after MBS and matched the pre-pregnancy controls. Upon extraction of offspring growth patterns and mediation analyses of maternal weight loss and metabolic responses to MBS, study findings will investigate effects of preconception weight loss by MBS on short- and long-term child health outcomes. Results will guide future studies focusing on improving maternal preconception weight and maternal-fetal outcomes.
Authors
- Kimberly K. Vesco (ORCID: https://orcid.org/0000-0001-9934-6383)
- Darios Getahun (ORCID: https://orcid.org/0000-0003-3610-8841)
- Sijia Qiu (ORCID: https://orcid.org/0000-0002-4828-3180)
- Theresa M. Im (ORCID: https://orcid.org/0000-0001-6688-9146)
- Caryn Etsuko Shima Oshiro (ORCID: https://orcid.org/0000-0002-0802-9794)
- Jiaxiao Shi (ORCID: https://orcid.org/0000-0001-8397-3729)
- Jonathan Q. Purnell (ORCID: https://orcid.org/0000-0001-5505-6333)
- Janne Boone‐Heinonen (ORCID: https://orcid.org/0000-0002-0368-0545)
- Carmen P. Wong (ORCID: https://orcid.org/0000-0001-8294-2584)
- Padma Koppolu
Institutions
- Kaiser Permanente (US)
- Oregon Health & Science University (US)
- University of California, San Francisco (US)
- Kaiser Permanente Center for Health Research (US)
Publication Details
- Journal
- medRxiv
- Published
- 2026-04-24
- DOI
- https://doi.org/10.64898/2026.04.22.26351521
- Primary Topic
- Gestational Diabetes Research and Management
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Eli Lilly and Company
- AstraZeneca
- Verily Life Sciences
- National Institutes of Health
- National Heart, Lung, and Blood Institute