CT-based AI system for quantitative and integrated management of acute respiratory distress syndrome in critical care
-based monitoring for noninvasive severity stratification and ventilation management; and (4) predicted 28-day outcomes (time-averaged AUC = 0.79), providing complementary risk assessment for clinical planning. Further analyses confirm generalizability to ARDS-associated right ventricular dysfunction (AUC = 0.76) and revealed a positive shift image-derived age residuals, reflecting disease-related imaging patterns that resemble pulmonary aging. By bridging visual information with quantitative physiology, AutoARDS exemplifies a scalable blueprint for transforming chest CT into an integrated, quantitative platform for precise and reproducible critical-care management.
Authors
- Jiannan Zhang (ORCID: https://orcid.org/0000-0001-7401-7401)
- Quankuan Gu
- Yaxin Xiong (ORCID: https://orcid.org/0009-0006-9771-5134)
- Hui Chen (ORCID: https://orcid.org/0000-0002-8944-0090)
- Zhaowen Qiu (ORCID: https://orcid.org/0000-0001-5292-0333)
- Yingnan Ju (ORCID: https://orcid.org/0000-0001-5498-332X)
- Ping Hang
- Peiyao Luo (ORCID: https://orcid.org/0000-0002-7284-4048)
- Qiu Tinghui
- Xianglin Meng (ORCID: https://orcid.org/0000-0001-5091-3260)
- Zhongheng Zhang (ORCID: https://orcid.org/0000-0002-2336-5323)
- Yuetan Chu (ORCID: https://orcid.org/0000-0003-1729-831X)
- Ci Han
- Qiuyue Yang
- Xin Ge
- Xin Gao
- Kai Kang
- Xiqing Luo
- Yilan Zhang
- Yaoyu Gu
- Mingbo Zhao
- Renpei Lu
- Yiqi Wang
- Changsong Wang
- Jiaman Guan
- Hongyu Shi
- Kaijiang Yu
- Jiuyue Sun
- Mingyan Zhao
- Yi Ru-Ya Zhang
- Jianpeng Wang
- Gongning Luo
Institutions
- Harbin Medical University (CN)
- Sir Run Run Shaw Hospital (CN)
- Soochow University (CN)
- Fudan University Shanghai Cancer Center (CN)
- Zhongda Hospital Southeast University (CN)
- Hainan General Hospital (CN)
- Wuxi Ninth People's Hospital (CN)
- First Affiliated Hospital of Harbin Medical University (CN)
- Northeast Forestry University (CN)
- King Abdullah University of Science and Technology (SA)
- Hainan Medical University (CN)
Publication Details
- Journal
- npj Digital Medicine
- Published
- 2026-04-24
- DOI
- https://doi.org/10.1038/s41746-026-02648-9
- Primary Topic
- Respiratory Support and Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China